This post has been edited and revised many times over, each time with a slightly better version of running Theme Hospital on the Mac.

As of today, this is the best way to run Theme Hospital on your Mac, in high resolution thanks to the work of the open-source clone of Theme Hospital from CorsixTH.

Here’s what you’ll need to get started. You will need an original installation or CD image of Theme Hospital. If you don’t have one, you can buy it from Gog.com or the free TH demo works just the same.

Once you have that, you need to download the latest release of CorsixTH, available here (version as of this post is v 0.40).

Install CorsixTH like any normal Mac app, then launch “CorsixTH”. The app will ask you to point it to the directory where Theme Hospital files are. Do that.

Then play! It can’t be any simpler. And best of all, thanks to CorsixTH’s clone, all of the graphics and sounds have been updated to work on high-resolution displays. The game looks wonderful!

Enjoy!

ᔥ Reddit